Polarity in Stem Cell Division: Asymmetric Stem Cell Division in Tissue Homeostasis
نویسندگان
چکیده
منابع مشابه
Polarity in stem cell division: asymmetric stem cell division in tissue homeostasis.
Many adult stem cells divide asymmetrically to balance self-renewal and differentiation, thereby maintaining tissue homeostasis. Asymmetric stem cell divisions depend on asymmetric cell architecture (i.e., cell polarity) within the cell and/or the cellular environment. In particular, as residents of the tissues they sustain, stem cells are inevitably placed in the context of the tissue architec...
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Stem cells self-renew but also give rise to daughter cells that are committed to lineage-specific differentiation. To achieve this remarkable task, they can undergo an intrinsically asymmetric cell division whereby they segregate cell fate determinants into only one of the two daughter cells. Alternatively, they can orient their division plane so that only one of the two daughter cells maintain...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2009
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a001313